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Scientific Publications

In the context of our collaborations, we have significantly contributed to numerous articles published in peer-reviewed journals. Please find below a list of selected publications:

Catumaxomab / EpCAM

Immunomonitoring Results of a Phase II/III Study in malignant ascites patients with the Trifunctional Antibody Catumaxomab (anti-EpCAM x anti-CD3). JägerM, SchoberthA, RufP, HessJ, HennigM, SchmalfeldtB, WimbergP, StröhleinMA, TheissenB, HeissMM, LindhoferH, Cancer Res. 2011 Nov. 1undefined See abstract

Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients.Ruf P, Kluge M, Jäger M, Burges A, Volovat C, Heiss MM, Hess J, Wimberger P, Brandt B, Lindhofer H.
Br J Clin Pharmacol. 2010 Jun
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Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action. Hirschhaeuser F, Walenta S, Mueller-Klieser W. Cancer Immunol Immunother. 2010 Jul 21.
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Palliative treatment of malignant ascites: profile of catumaxomab. Ammouri L, Prommer EE. 2010 May 25;4:103-10.
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The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial. Heiss MM, Murawa P, Koralewski P, Kutarska E, Kolesnik OO, Ivanchenko VV, Dudnichenko AS, Aleknaviciene B, Razbadauskas A, Gore M, Ganea-Motan E, Ciuleanu T, Wimberger P, Schmittel A, Schmalfeldt B, Burges A, Bokemeyer C, Lindhofer H, Lahr A, Parsons SL. Int J Cancer. 2010 Apr 27.
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Structural and functional characterization of the trifunctional antibody catumaxomab.
Chelius D, Ruf P, Gruber P, Plöscher M, Liedtke R, Gansberger E, Hess J, Wasiliu M, Lindhofer H. MAbs. 2010 May 16;2(3).
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Development and approval of the trifunctional antibody catumaxomab (anti-EpCAMxanti-CD3) as a targeted cancer immunotherapy. Seimetz D, Lindhofer H, Bokemeyer C. Cancer Treat Rev. 2010 Mar 26.
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Catumaxomab: Clinical development and future directions.Linke R, Klein A, Seimetz D. MAbs. 2010 Mar 16;2(2).
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Test system for trifunctional antibodies in 3D MCTS culture. Hirschhaeuser F, Leidig T, Rodday B, Lindemann C, Mueller-Klieser W. J Biomol Screen. 2009 Sep;14(8):980-90. Epub 2009 Aug 12.
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Current and future options in the treatment of malignant ascites in ovarian cancer.
Woopen H, Sehouli J. Anticancer Res. 2009 Aug;29(8):3353-9.
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Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies. Ströhlein MA, Heiss MM. J Surg Oncol. 2009 Sep 15;100(4):329-30.
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Catumaxomab: A bispecific trifunctional antibody. Sebastian M, Kuemmel A, Schmidt M, Schmittel A. Drugs Today (Barc). 2009 Aug;45(8):589-97.
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Bispecific antibodies for cancer therapy. Chames P, Baty D. Curr Opin Drug Discov Devel. 2009 Mar;12(2):276-83.
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Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x Anti-CD3): results of a phase 1/2 study. Sebastian M et al. J Immunother. 2009 Feb-Mar;32(2):195-202.
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Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis. Ströhlein MA, Siegel R, Jäger M, Lindhofer H, Jauch KW, Heiss MM. J Exp Clin Cancer Res. 2009 Feb 14;28:18.
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The evolving role of catumaxomab in gastric cancer. Lordick F. et al., Expert Opin Biol Ther. 2008 Sep;8(9):1407-15.
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Induction of long-lasting antitumor immunity by concomitant cell therapy with allogeneic lymphocytes and trifunctional bispecific antibody. Morecki S, Lindhofer H, Yacovlev E, Gelfand Y, Ruf P, Slavin S. Exp Hematol. 2008 Aug;36(8):997-1003.
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Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study. Sebastian M, Passlick B, Friccius-Quecke H, Jäger M, Lindhofer H, Kanniess F, Wiewrodt R, Thiel E, Buhl R, Schmittel A. Cancer Immunol Immunother. 2007 Oct;56(10):1637-44. Epub 2007 Apr 5.
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EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges. Chaudry MA, Sales K, Ruf P, Lindhofer H, Winslet MC.Br J Cancer. 2007 Apr 10;96(7):1013-9.
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Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer. Ruf P. et al., Br J Cancer. 2007 Aug 6;97(3):315-21.
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Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study. Burges A. et al., Clin Cancer Res. 2007 July 1;13, 3899-3905
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Prednisolone reduces TNF-alpha release by PBMCs activated with a trifunctional bispecific antibody but not their anti-tumor activity. Walz A. et al., Anticancer Res. 2005 Nov-Dec;25(6B):4239-43.
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Immunotherapy of malignant ascites with trifunctional antibodies. Heiss, M. M. et al., Int J Cancer. 2005 Nov 10;117(3):435-43.
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Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Ruf P, Lindhofer H. Blood. 2001 Oct 15;98(8):2526-34
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Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. Lindhofer H, Mocikat R, Steipe B, Thierfelder S. J Immunol. 1995 Jul 1;155(1):219-25
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Ertumaxomab / HER2

The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Jäger M, Schoberth A, Ruf P, Hess J, Lindhofer H. Cancer Res. 2009 May 15;69(10):4270-6.
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Ertumaxomab: a trifunctional antibody for breast cancer treatment. Philipp Kiewe & Eckhard Thiel, Expert Opin Investig Drugs. 2008 Oct;17(10):1553-8.
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Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer. Kiewe P. et al., Clin Cancer Res. 2006 May 15;12(10):3085-91
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Lasting remission following multimodal treatment in a patient with metastatic breast cancer. Stemmler H. J. et al., Anticancer Drugs. 2005 Nov;16(10):1135-1137.
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FBTA05/ Lymphomun / CD20

Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion. Buhmann et al., Bone Marrow Transplant. 2008 Oct 13.
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Bi20 (FBTA05), a novel trifunctional bispecific antibody (anti-CD20 x anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels. Stanglmaier et al., Int J Cancer. 2008 Sep 1;123(5):1181-9.
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Use of trifunctional bispecific antibodies to prevent graft-versus-host disease induced by allogeneic lymphocytes. Morecki S. et al., Blood. 2006 Feb 15;107(4):1564-9
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TRBS07/ Ektomab/ Ektomun/ GD2

Two new trifunctional antibodies for the therapy of human malignant melanoma. Ruf P. et al., Int J Cancer. 2004 Feb 20;108(5):725-32.
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Increased chondroitin sulphate proteoglycan expression (B5 immunoreactivity) in metastases of uveal melanoma. Kiewe P, Bechrakis NE, Schmittel A, Ruf P, Lindhofer H, Thiel E, Nagorsen D. Ann Oncol. 2006 Dec;17(12):1830-4.
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