Wissenschaftliche Publikationen
Trion ResearchWissenschaftliche Publikationen | Veröffentlichungen
Im Rahmen unserer Kooperationen haben wir wesentlich zur Publikation zahlreicher Artikel in renommierten Fachzeitschriften beigetragen. Hier finden Sie eine Auswahl von Publikationen zu folgenden Themen:
Catumaxomab / EpCAM
Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study. Andreas Winter , Kai Zacharowski , Patrick Meybohm , Andreas Schnitzbauer , Peter Ruf 5, Claudia Kellermann , Horst Lindhofer BMC Anesthesiol. 2021 Oct 29;21(1):261. doi: 10.1186/s12871-021-01479-3 | SEE ABSTRACT
First time intravesically administered trifunctional antibody catumaxomab in patients with recurrent non-muscle invasive bladder cancer indicates high tolerability and local immunological activity. Ruf P, Bauer HW, Schoberth A, Kellermann C, Lindhofer H. Cancer Immunol Immunother 2021 April 10. doi: 10.1007/s00262-021-02930-7. Online ahead of print | SEE ABSTRACT
Randomised phase II trial to investigate catumaxomab (anti-EpCAM × anti-CD3) for treatment of peritoneal carcinomatosis in patients with gastric cancer. Knödler M, Körfer J, Kunzmann V, Trojan J, Daum S, Schenk M, Kullmann F, Schroll S, Behringer D, Stahl M, Al-Batran SE, Hacker U, Ibach S, Lindhofer H, Lordick F. Br J Cancer. 2018 Aug;119(3):296-302. doi: 10.1038/s41416-018-0150-6. Epub 2018 Jul 10 | SEE ABSTRACT
The role of relative lymphocyte count as a biomarker for the effect of catumaxomab on survival in malignant ascites patients: results from a phase II/III study. Heiss MM, Ströhlein MA, Bokemeyer C, Arnold D, Parsons SL, Seimetz D, Lindhofer H, Schulze E, Hennig M. Clin. Cancer Res. 2014 June | SEE ABSTRACT
First patient treated with a re-challenge of catumaxomab in recurrent malignant ascites: a case report. Klaus Pietzner, Michael Jäger, Alexandra Schoberth, Gülten Oskay-Özcelik, Marc Kuhberg, Horst Lindhofer, Jalid Sehouli. Med. Oncol. 2012 June | SEE ABSTRACT
Humoral response to catumaxomab correlates with clinical outcome: Results of the pivotal phase II/III study in patients with malignant ascites. Marion G Ott, Frederik Marmé, Gerhard Moldenhauer, Horst Lindhofer, Michael Hennig, Rolf Spannagl, Mirko M Essing, Rolf Linke, and Diane Seimetz. Int. J. Cancer. 2012 May | SEE ABSTRACT
Immunomonitoring Results of a Phase II/III Study in malignant ascites patients with the Trifunctional Antibody Catumaxomab (anti-EpCAM x anti-CD3). JägerM, SchoberthA, RufP, HessJ, HennigM, SchmalfeldtB, WimbergP, StröhleinMA, TheissenB, HeissMM, LindhoferH, Cancer Res. 2011 Nov. 1 | SEE ABSTRACT
Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients. Ruf P, Kluge M, Jäger M, Burges A, Volovat C, Heiss MM, Hess J, Wimberger P, Brandt B, Lindhofer H.
Br J Clin Pharmacol. 2010 Jun | SEE ABSTRACT
Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action. Hirschhaeuser F, Walenta S, Mueller-Klieser W. Cancer Immunol Immunother. 2010 Jul 21. | SEE ABSTRACT
Palliative treatment of malignant ascites: profile of catumaxomab. Ammouri L, Prommer EE. 2010 May 25;4:103-10. | SEE ABSTRACT
The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial. Heiss MM, Murawa P, Koralewski P, Kutarska E, Kolesnik OO, Ivanchenko VV, Dudnichenko AS, Aleknaviciene B, Razbadauskas A, Gore M, Ganea-Motan E, Ciuleanu T, Wimberger P, Schmittel A, Schmalfeldt B, Burges A, Bokemeyer C, Lindhofer H, Lahr A, Parsons SL. Int J Cancer. 2010 Apr 27. | SEE ABSTRACT
Structural and functional characterization of the trifunctional antibody catumaxomab. Chelius D, Ruf P, Gruber P, Plöscher M, Liedtke R, Gansberger E, Hess J, Wasiliu M, Lindhofer H. MAbs. 2010 May 16;2(3). | SEE ABSTRACT
Development and approval of the trifunctional antibody catumaxomab (anti-EpCAMxanti-CD3) as a targeted cancer immunotherapy. Seimetz D, Lindhofer H, Bokemeyer C. Cancer Treat Rev. 2010 Mar 26. | SEE ABSTRACT
Catumaxomab: Clinical development and future directions. Linke R, Klein A, Seimetz D. MAbs. 2010 Mar 16;2(2). | SEE ABSTRACT
Test system for trifunctional antibodies in 3D MCTS culture. Hirschhaeuser F, Leidig T, Rodday B, Lindemann C, Mueller-Klieser W. J Biomol Screen. 2009 Sep;14(8):980-90. Epub 2009 Aug 12. | SEE ABSTRACT
Current and future options in the treatment of malignant ascites in ovarian cancer.
Woopen H, Sehouli J. Anticancer Res. 2009 Aug;29(8):3353-9. | SEE ABSTRACT
Intraperitoneal immunotherapy to prevent peritoneal carcinomatosis in patients with advanced gastrointestinal malignancies. Ströhlein MA, Heiss MM. J Surg Oncol. 2009 Sep 15;100(4):329-30. | SEE ABSTRACT
Catumaxomab: A bispecific trifunctional antibody. Sebastian M, Kuemmel A, Schmidt M, Schmittel A. Drugs Today (Barc). 2009 Aug;45(8):589-97. | SEE ABSTRACT
Bispecific antibodies for cancer therapy. Chames P, Baty D. Curr Opin Drug Discov Devel. 2009 Mar;12(2):276-83. | SEE ABSTRACT
Treatment of malignant pleural effusion with the trifunctional antibody catumaxomab (Removab) (anti-EpCAM x Anti-CD3): results of a phase 1/2 study. Sebastian M et al. J Immunother. 2009 Feb-Mar;32(2):195-202. | SEE ABSTRACT
Induction of anti-tumor immunity by trifunctional antibodies in patients with peritoneal carcinomatosis. Ströhlein MA, Siegel R, Jäger M, Lindhofer H, Jauch KW, Heiss MM. J Exp Clin Cancer Res. 2009 Feb 14;28:18. | SEE ABSTRACT
The evolving role of catumaxomab in gastric cancer. Lordick F. et al., Expert Opin Biol Ther. 2008 Sep;8(9):1407-15. | SEE ABSTRACT
Induction of long-lasting antitumor immunity by concomitant cell therapy with allogeneic lymphocytes and trifunctional bispecific antibody. Morecki S, Lindhofer H, Yacovlev E, Gelfand Y, Ruf P, Slavin S. Exp Hematol. 2008 Aug;36(8):997-1003. | SEE ABSTRACT
Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM x anti-CD3): a phase I study. Sebastian M, Passlick B, Friccius-Quecke H, Jäger M, Lindhofer H, Kanniess F, Wiewrodt R, Thiel E, Buhl R, Schmittel A. Cancer Immunol Immunother. 2007 Oct;56(10):1637-44. Epub 2007 Apr 5. | SEE ABSTRACT
EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges. Chaudry MA, Sales K, Ruf P, Lindhofer H, Winslet MC.Br J Cancer. 2007 Apr 10;96(7):1013-9. | SEE ABSTRACT
Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer. Ruf P. et al., Br J Cancer. 2007 Aug 6;97(3):315-21. | SEE ABSTRACT
Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study. Burges A. et al., Clin Cancer Res. 2007 July 1;13, 3899-3905 | SEE ABSTRACT
Prednisolone reduces TNF-alpha release by PBMCs activated with a trifunctional bispecific antibody but not their anti-tumor activity. Walz A. et al., Anticancer Res. 2005 Nov-Dec;25(6B):4239-43. | SEE ABSTRACT
Immunotherapy of malignant ascites with trifunctional antibodies. Heiss, M. M. et al., Int J Cancer. 2005 Nov 10;117(3):435-43. | SEE ABSTRACT
Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Ruf P, Lindhofer H. Blood. 2001 Oct 15;98(8):2526-34 | SEE ABSTRACT
Preferential species-restricted heavy/light chain pairing in rat/mouse quadromas. Implications for a single-step purification of bispecific antibodies. Lindhofer H, Mocikat R, Steipe B, Thierfelder S. J Immunol. 1995 Jul 1;155(1):219-25 | SEE ABSTRACT
Ertumaxomab / HER 2
A phase I trial of the trifunctional anti Her2 × anti CD3 antibody ertumaxomab in patients with advanced solid tumors. Haense N, Atmaca A, Pauligk C, Steinmetz K, Marmé F, Haag GM, Rieger M, Ottmann OG, Ruf P, Lindhofer H, Al-Batran SE.BMC Cancer. 2016 July | SEE ABSTRACT
The trifunctional antibody ertumaxomab destroys tumor cells that express low levels of human epidermal growth factor receptor 2. Jäger M, Schoberth A, Ruf P, Hess J, Lindhofer H. Cancer Res. 2009 May 15;69(10):4270-6. | SEE ABSTRACT
Ertumaxomab: a trifunctional antibody for breast cancer treatment. Philipp Kiewe & Eckhard Thiel, Expert Opin Investig Drugs. 2008 Oct;17(10):1553-8. | SEE ABSTRACT
Phase I trial of the trifunctional anti-HER2 x anti-CD3 antibody ertumaxomab in metastatic breast cancer. Kiewe P. et al., Clin Cancer Res. 2006 May 15;12(10):3085-91 | SEE ABSTRACT
Lasting remission following multimodal treatment in a patient with metastatic breast cancer. Stemmler H. J. et al., Anticancer Drugs. 2005 Nov;16(10):1135-1137. | SEE ABSTRACT
Bi20 (FBTA05) / CD20 / Lymphomun
Immunotherapy with the trifunctional anti-CD20 × anti-CD3 antibody FBTA05 in a patient with relapsed t(8;14)-positive post-transplant lymphoproliferative disease. Kieslich A, Ruf P, Lindhofer H, Buhmann R, Eggert A, Hundsdoerfer P. Leuk Lymphoma. 2017 Aug;58(8):1989-1992. doi: 10.1080/10428194.2016.1272687. Epub 2017 Jan 16 | SEE ABSTRACT
Bispecific and Multivalent Antibodies – New Swords to Combat Hematological Malignancies Pp. 81-131 (51) Michael Stanglmaier and Juergen Hess. Published in Frontiers in Clinical Drug Research: Hematology Volume: 2 eISBN: 978-1-68108-181-6. 2016
Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R. Br. J. Haematol. 2015 April | SEE ABSTRACT
Immunotherapy with FBTA05 (Bi20), a trifunctional bispecific anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion (DLI) in relapsed or refractory B-cell lymphoma after allogeneic stem cell transplantation: study protocol of an investigator-driven, open-label, non-randomized, uncontrolled, dose-escalating Phase I/II-trial. Buhmann R, Stanglmaier M , Hess J, Lindhofer H, Peschel C, Kolb HJ.J Transl. Med. 2013 July | SEE ABSTRACT
Immunotherapy of recurrent B-cell malignancies after allo-SCT with Bi20 (FBTA05), a trifunctional anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion. Buhmann et al., Bone Marrow Transplant. 2008 Oct 13. | SEE ABSTRACT
Bi20 (FBTA05), a novel trifunctional bispecific antibody (anti-CD20 x anti-CD3), mediates efficient killing of B-cell lymphoma cells even with very low CD20 expression levels. Stanglmaier et al., Int J Cancer. 2008 Sep 1;123(5):1181-9. | SEE ABSTRACT
Use of trifunctional bispecific antibodies to prevent graft-versus-host disease induced by allogeneic lymphocytes. Morecki S. et al., Blood. 2006 Feb 15;107(4):1564-9 | SEE ABSTRACT
Ektomun / GD2
GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma. Felix Zirngibl , Sara M Ivasko , Laura Grunewald Anika Klaus , Silke Schwiebert , Peter Ruf , Horst Lindhofer , Kathy Astrahantseff , Lena Andersch , Johannes H Schulte , Holger N Lode , Angelika Eggert , Kathleen Anders , Patrick Hundsdoerfer , Annette Künkele J Immunother Cancer. 2021 Jul;9(7): e002923. doi: 10.1136/jitc-2021-002923 | SEE ABSTRACT
Two new trifunctional antibodies for the therapy of human malignant melanoma. Ruf P. et al., Int J Cancer. 2004 Feb 20;108(5):725-32. | SEE ABSTRACT
Increased chondroitin sulphate proteoglycan expression (B5 immunoreactivity) in metastases of uveal melanoma. Kiewe P, Bechrakis NE, Schmittel A, Ruf P, Lindhofer H, Thiel E, Nagorsen D. Ann Oncol. 2006 Dec;17(12):1830-4. | SEE ABSTRACT
Ganglioside GD2-specific trifunctional surrogate antibody Surek demonstrates therapeutic activity in a mouse melanoma model. Peter Ruf, Beatrix Schäfer, Nina Eissler, Ralph Mocikat, Juergen Hess, Matthias Plöscher, Susanne Wosch, Ivonne Suckstorff, Christine Zehetmeier and Horst Lindhofer. J Transl. Med. 2012 November | SEE ABSTRACT
Trifunctional bispecific antibodies induce tumor-specific T cells and elicit a vaccination effect. Eissler N, Ruf P, Mysliwietz J, Lindhofer H, Mocikat R. Cancer Res. 2012 August | SEE ABSTRACT
Potential of the trifunctional bispecific antibody surek depends on dendritic cells: rationale for a new approach of tumor immunotherapy. Eissler N, Mysliwietz J, Deppisch N, Ruf P, Lindhofer H, Mocikat R. Mol. Med. 2013 April | SEE ABSTRACT
Efficacy and Tolerability of a GD2-Directed Trifunctional Bispecific Antibody in a Preclinical Model: Subcutaneous Administration Is Superior to Intravenous Delivery. Deppisch N, Ruf P, Eissler N, Neff F, Buhmann R, Lindhofer H, Mocikat R. Mol. Cancer Ther. 2015 August | SEE ABSTRACT
Potent CD4+ T cell-associated antitumor memory responses induced by trifunctional bispecific antibodies in combination with immune checkpoint inhibition. Deppisch N, Ruf P, Eißler N, Lindhofer H, Mocikat R. Oncotarget. 2017 Jan 17;8(3):4520-4529. doi: 10.18632/oncotarget.13888 | SEE ABSTRACT
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